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Dubey, Nitin
- Simultaneous Estimation of Atorvastatin, Clopidogrel and Aspirin in Capsule Dosage Forms Using UV-Spectroscopy
Abstract Views :173 |
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Authors
Affiliations
1 College of Pharmacy, IPS Academy, Rajendar Nagar, Indore [Madhya Pradesh], IN
1 College of Pharmacy, IPS Academy, Rajendar Nagar, Indore [Madhya Pradesh], IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 4 (2010), Pagination: 885-887Abstract
Atorvastatin [R-(R*,R*)]-2-(4-fluorophenyl)-β, δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenyl amino)carbonyl]-1H-pyrrole 1-heptanoic acid an Anti-hyperlipidemia and Clopidogrel (2-Chloro phenyl, 6-7 dihydro4H thieno [3,2-c]pyridine-5-yl)acetic acid is an Anti-platelet drug and Aspirin (2-Acetoxy benzoic acid) an NSAIDs. This paper presents two methods i.e. first derivative spectrophotometery and multicomponent spectrophotometery for simultaneous estimation of these three drugs combination in pharmaceutical formulations. The first derivative amplitudes at 276, 226 and 222 nm were utilized for simultaneous estimations. The multicomponent amplitudes at 247, 220 and 235 nm were utilizatied. Proper selection of wavelength for estimations of one drug by other in derivative spectra and multicomponent lead to successful development of methods for simultaneous estimation. The results of analysis were validated statistically that included parameters such as precision, LOD, LOQ, recovery and robustness. Both methods were simple, economical, accurate, reproducible and precise.Keywords
Simultaneous Determination, Derivative Spectroscopy, Multicomponent Method.- A Selective High Performance Liquid Chromatographic Method for Estimation of Catechin in Ayurvedic Taila Preparations
Abstract Views :172 |
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Authors
Affiliations
1 School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore [M.P], IN
2 College of Pharmacy, IPS Academy, Indore [M.P], IN
3 A. R. College of Pharmacy, Vallabh Vidyanagar [Gujarat], IN
1 School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore [M.P], IN
2 College of Pharmacy, IPS Academy, Indore [M.P], IN
3 A. R. College of Pharmacy, Vallabh Vidyanagar [Gujarat], IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 1 (2009), Pagination: 66-69Abstract
A simple, sensitive, rapid and selective high-performance liquid chromatographic (HPLC) method has been developed and validated for the analysis of catechin in marketed Ayurvedic Taila (oil) formulations containing Acacia catechu. Chromatography of methanolic: 0.1% formic acid (7:3, v/v) extracts of these formulations was performed on C18 (5 μm×25 cm×4.6 mm i.d) column using isocratic mobile phase consisting of methanol:acetonitrile:water (40:15:45, v/v/v) containing 1.0% acetic acid at a flow rate of 0.5 ml/min and SPD-10 AVP photodiode array (PDA) UV-Visible detector. The analytical marker, catechin, was quantified at 279 nm. The retention time of catechin was about 3.27 min. The linear regression analysis data for the calibration plot showed a good linear relationship with correlation coefficient of 0.9988 in the concentration range of 15 to 90 μg/ml for catechin with respect to peak area. The limit of detection and limit of quantitation values were found to be 0.5 μg/ml and 1.7 μg/ml respectively. Repeatability of the method was found to be 0.62 RSD. Recovery values from 99.73 to 100.22% indicate excellent accuracy of the method. The developed HPLC method is accurate, precise, and cost-effective, and it can be successfully applied for the determination of catechin in marketed ayurvedic oil formulations containing Acacia catechu.Keywords
Acacia catechu, HPLC, Oil, Quantitation.- Quality Assessment of Kushta-e-Gaodanti:A Traditional Unani Medicine
Abstract Views :148 |
PDF Views:0
Authors
Affiliations
1 College of Pharmacy, IPS Academy, Indore [M.P], IN
2 School of Pharmacy, Devi Ahilya University, Indore [M.P], IN
3 A R College of Pharmacy, Vallabh Vidyanagar [Gujarat], IN
1 College of Pharmacy, IPS Academy, Indore [M.P], IN
2 School of Pharmacy, Devi Ahilya University, Indore [M.P], IN
3 A R College of Pharmacy, Vallabh Vidyanagar [Gujarat], IN